The clock-like accumulation of germline and somatic mutations can arise from the interplay of DNA damage and repair.

Abstract excerpt

The rates at which mutations accumulate across human cell types vary. To identify causes of this variation, mutations are often decomposed into a combination of the single-base substitution (SBS) "signatures" observed in germline, soma, and tumors, with the idea that each signature corresponds to one or a small number of underlying mutagenic processes. Two such signatures turn out to be ubiquitous across cell...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to DNA Damage
• Share to DNA Methylation
• Share to DNA Repair