Article

Transcription initiation profiling defines the regulatory logic of astrocyte gene regulation

2026-05-04

Abstract excerpt

Astrocytes are central regulators of neuroinflammation, yet the mechanisms by which they convert common inflammatory signals into cell type-specific transcriptional responses remain poorly understood. Here we mapped transcription initiation genome-wide in primary mouse astrocytes stimulated with interleukin-1B (IL-1B) and defined the active regulatory elements that drive astrocyte reactivity. We find that inducibl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e90b7c8c-2e7b-5cfc-badd-06f577c54d6e
DOI: 10.64898/2026.05.03.722406

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcription initiation profiling defines the regulatory logic of astrocyte gene regulationDOI 10.64898/2026.05.03.722406Read

KOLF2.1J iTF-Microglia: A standardized platform to study microglial transcriptional regulatory networks in CNS diseaseSemantic proximity Read

Transcriptional control of microglia phenotypes in health and disease.Semantic proximity Read

The lncRNA <i>Gm16685</i> / <i>MITA1</i> modulates inflammatory astrocyte reactivity through PCBP2 associated regulation of IKKβ signalingSemantic proximity Read

Multi-tier signaling and epigenomic reprogramming orchestrate microglial inflammatory states and functions associated with demyelinationSemantic proximity Read

Reprogramming of neuronal genome function and phenotype by astrocytesSemantic proximity Read

Exploiting dynamic enhancer landscapes to decode macrophage and microglia phenotypes in health and disease.Semantic proximity Read

Comprehensive profiling of transcription factors for reprogramming human astrocytes to neuronal cells through endogenous CRISPR-based gene activationSemantic proximity Read

Deciphering microglia phenotypes in health and disease.Semantic proximity Read

CRISPRi screens in human astrocytes elucidate regulators of distinct inflammatory reactive statesSemantic proximity Read

The Neurogenic Potential of Astrocytes Is Regulated by Inflammatory Signals.Semantic proximity Read

Gene regulatory networks controlling temporal patterning, neurogenesis, and cell fate specification in the mammalian retinaSemantic proximity Read

IRF8 configures enhancer landscape in postnatal microglia and directs microglia specific transcriptional programsSemantic proximity Read