Article

Gene regulatory networks controlling temporal patterning, neurogenesis, and cell fate specification in the mammalian retina

2021-08-02

Abstract excerpt

Gene regulatory networks (GRNs), consisting of transcription factors and their target cis- regulatory sequences, control neurogenesis and cell fate specification in the developing central nervous system, but their organization is poorly characterized. In this study, we performed integrated single-cell RNA- and scATAC-seq analysis in both mouse and human retina to profile dynamic changes in gene expression, chromat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ea783a3a-8e4e-5aad-b3d4-ffb334538736
DOI: 10.1101/2021.07.31.454200

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gene regulatory networks controlling temporal patterning, neurogenesis, and cell fate specification in the mammalian retinaDOI 10.1101/2021.07.31.454200Read

Spatiotemporal single cell analyses reveal a transient population of retinal progenitor cells in the ciliary margin of developing human retinaSemantic proximity Read

A multi-omics atlas of the human retina at single-cell resolutionSemantic proximity Read

Chromatin accessibility analysis reveals regulatory dynamics of developing human retina and hiPSC-derived retinal organoidsSemantic proximity Read

A conserved enhancer cluster regulates <i>efnb2</i> expression in the vertebrate dorsal retinaSemantic proximity Read

A comprehensive series of temporal transcription factors in the fly visual systemSemantic proximity Read

Deciphering the spatio-temporal transcriptional and chromatin accessibility of human retinal organoid development at the single cell levelSemantic proximity Read

Single-cell analyses reveal transient retinal progenitor cells in the ciliary margin of developing human retinaSemantic proximity Read

Single Cell Multiome Atlas of the Human Developing RetinaSemantic proximity Read

Epigenomic Profiling and Single-Nucleus-RNA-Seq Reveal <i>Cis</i> -Regulatory Elements in Human Retina, Macula and RPE and Non-Coding Genetic VariationSemantic proximity Read

Cross-species transcriptomic and epigenomic analysis reveals key regulators of injury response and neuronal regeneration in vertebrate retinasSemantic proximity Read

Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling developmentSemantic proximity Read

Otx2 and Oc1 directly regulate the transcriptional program of cone photoreceptor developmentSemantic proximity Read