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Article

Transcriptional control of microglia phenotypes in health and disease.

The Journal of clinical investigation - 1 Sept 2017

Holtman Inge R, Skola Dylan, Glass Christopher K

Abstract excerpt

Microglia are the main resident macrophage population of the CNS and perform numerous functions required for CNS development, homeostasis, immunity, and repair. Many lines of evidence also indicate that dysregulation of microglia contributes to the pathogenesis of neurodegenerative and behavioral diseases. These observations provide a compelling argument to more clearly define the mechanisms that control...

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Identifiers

PMID: 28758903
DOI: 10.1172/JCI90604
PMCID: PMC5669536

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