Article

Epistatic contributions to human traits via transcription factor mechanisms

2025-09-29

Abstract excerpt

Epistasis causes an individual’s genetic background to modulate a DNA variant’s effect on trait [1–6]. Epistatic interactions among different loci in human complex traits are expected to be widespread but have not been found [7]. This could be due to small interaction effect sizes, the statistical complexity of estimating interactions that is higher than marginal variant effects, and a substantial multiple testing...

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Literature Corpus work: e90947a7-bd58-5142-b8bf-c8f67cebebd8
DOI: 10.1101/2025.09.28.25336826

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