Article
The Genetics of Transcription Factor DNA Binding Variation.
Cell - 28 Jul 2016
Deplancke Bart, Alpern Daniel, Gardeux Vincent
Abstract excerpt
Most complex trait-associated variants are located in non-coding regulatory regions of the genome, where they have been shown to disrupt transcription factor (TF)-DNA binding motifs. Variable TF-DNA interactions are therefore increasingly considered as key drivers of phenotypic variation. However, recent genome-wide studies revealed that the majority of variable TF-DNA binding events are not driven by sequence...
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