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Article

Are Interactions between cis-Regulatory Variants Evidence for Biological Epistasis or Statistical Artifacts?

American journal of human genetics - 6 Oct 2016

Fish Alexandra E, Capra John A, Bush William S

Abstract excerpt

The importance of epistasis-or statistical interactions between genetic variants-to the development of complex disease in humans has been controversial. Genome-wide association studies of statistical interactions influencing human traits have recently become computationally feasible and have identified many putative interactions. However, statistical models used to detect interactions can be confounded, which...

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Identifiers

PMID: 27640306
DOI: 10.1016/j.ajhg.2016.07.022
PMCID: PMC5065654

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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