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Coordinated Interaction: A model and test for globally signed epistasis in complex traits

2020-02-14

Abstract excerpt

Interactions between genetic variants – epistasis – is pervasive in model systems and can profoundly impact evolutionary adaption, population disease dynamics, genetic mapping, and precision medicine efforts. In this work we develop a model for structured polygenic epistasis, called Coordinated Interaction (CI), and prove that several recent theories of genetic architecture fall under the formal umbrella of CI. U...

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Literature Corpus work
8532b4d4-6671-5bd3-b0a3-e3abd07ac1fa
DOI
10.1101/2020.02.14.949883
Open publication

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Coordinated Interaction: A model and test for globally signed epistasis in complex traitsDOI 10.1101/2020.02.14.949883
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