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Article

Evidence for sex-specific genetic architectures across a spectrum of human complex traits.

Genome biology - 29 Jul 2016

Rawlik Konrad, Canela-Xandri Oriol, Tenesa Albert

Abstract excerpt

BACKGROUND: Sex differences are a common feature of human traits; however, the role sex determination plays in human genetic variation remains unclear. The presence of gene-by-sex (GxS) interactions implies that trait genetic architecture differs between men and women. Here, we show that GxS interactions and genetic heterogeneity among sexes are small but common features of a range of high-level complex traits....

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Share to Genetic Associations and Epidemiology
Share to Genetic Variation
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27473438
DOI: 10.1186/s13059-016-1025-x
PMCID: PMC4965887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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