Article
Detection and replication of epistasis influencing transcription in humans.
Nature - 10 Apr 2014
Hemani Gibran, Shakhbazov Konstantin, Westra Harm-Jan, Esko Tonu, Henders Anjali K, McRae Allan F, Yang Jian, Gibson Greg, Martin Nicholas G, Metspalu Andres, Franke Lude, Montgomery Grant W, Visscher Peter M, Powell Joseph E
Abstract excerpt
Epistasis is the phenomenon whereby one polymorphism's effect on a trait depends on other polymorphisms present in the genome. The extent to which epistasis influences complex traits and contributes to their variation is a fundamental question in evolution and human genetics. Although often demonstrated in artificial gene manipulation studies in model organisms, and some examples have been reported in other...
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