Article

NMNAT2 supports vesicular glycolysis via NAD homeostasis to fuel fast axonal transport

2023-05-19

Abstract excerpt

<title>Abstract</title> <p>Background Bioenergetic maladaptations and axonopathy are often found in the early stages of neurodegeneration. Nicotinamide adenine dinucleotide (NAD), an essential cofactor for energy metabolism, is mainly synthesized by Nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2) in CNS neurons. NMNAT2 mRNA levels are reduced in the brains of Alzheimer’s, Parkinson's, and Huntington’...

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Literature Corpus work: 14518829-76d1-5990-a832-0de748b07504
DOI: 10.21203/rs.3.rs-2859584/v1

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