Autism genes converge on asynchronous development of shared neuron classes.

doi:10.1038/s41586-021-04358-6

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Article

Autism genes converge on asynchronous development of shared neuron classes.

Nature - 1 Feb 2022

Paulsen Bruna, Velasco Silvia, Kedaigle Amanda J, Pigoni Martina, Quadrato Giorgia, Deo Anthony J, Adiconis Xian, Uzquiano Ana, Sartore Rafaela, Yang Sung Min, Simmons Sean K, Symvoulidis Panagiotis, Kim Kwanho, Tsafou Kalliopi, Podury Archana, Abbate Catherine, Tucewicz Ashley, Smith Samantha N, Albanese Alexandre, Barrett Lindy, Sanjana Neville E, Shi Xi, Chung Kwanghun, Lage Kasper, Boyden Edward S, Regev Aviv, Levin Joshua Z, Arlotta Paola

Abstract excerpt

Genetic risk for autism spectrum disorder (ASD) is associated with hundreds of genes spanning a wide range of biological functions1-6. The alterations in the human brain resulting from mutations in these genes remain unclear. Furthermore, their phenotypic manifestation varies across individuals7,8. Here we used organoid models of the human cerebral cortex to identify cell-type-specific developmental abnormalities...

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Identifiers

PMID: 35110736
DOI: 10.1038/s41586-021-04358-6
PMCID: PMC8852827

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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