Article

AI-driven framework modeling perturbation in brain organoids reveals candidate genes for autism

2026-08-26

Abstract excerpt

Autism gene discovery is constrained by the rarity and heterogeneity of damaging variants, requiring large cohorts to identify susceptibility genes. Neural organoids and single-cell foundation models enable perturbation modeling in neurodevelopmental contexts. Here, we show that perturbation-informed foundation modeling of neural organoids can provide functional context for prioritizing candidate genes with genomi...

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Literature Corpus work: 3bc001bb-b97a-5479-ac93-f5525e1ad634
DOI: 10.64898/2026.08.22.746387

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