Article

Cell-type specific developmental defects in <i>PTEN</i> -mutant cortical organoids converge on abnormal circuit activity

2022-11-16

Abstract excerpt

De novo heterozygous loss-of-function mutations in PTEN are strongly associated with Autism spectrum disorders (ASD); however, it is unclear how heterozygous mutations in this gene affects different cell types during human brain development, and how these effects vary across individuals. Here, we used human cortical organoids from different donors to identify cell-type-specific developmental events that are affec...

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Literature Corpus work: ac236f39-dd95-59d5-84f9-72d4acc5ab4d
DOI: 10.1101/2022.11.15.516664

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