Article

WWOX contributes to DNA damage, but not somatic instability in Huntington’s disease

2026-06-26

Abstract excerpt

Huntington’s disease (HD), caused by a CAG repeat expansion in the huntingtin ( HTT ) gene, is characterized by progressive neurodegeneration and accumulation of DNA damage with multiple disease-modifier genes involved in DNA repair pathways. Previous studies have implicated ataxia telangiectasia mutated (ATM) signaling in the regulation of genomic stability and DNA damage repair (DDR) pathways in HD. ATM has als...

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Literature Corpus work: e8db95f6-e7dc-5733-a042-aee0b7fd4208
DOI: 10.64898/2026.06.24.734331

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