Article

A CAG repeat threshold for therapeutics targeting somatic instability in Huntington’s disease

2023-12-15

Abstract excerpt

The Huntington’s disease mutation is a CAG repeat expansion in the huntingtin gene that results in an expanded polyglutamine tract in the huntingtin protein. The CAG repeat is unstable, and expansions of hundreds of CAGs have been detected in Huntington’s disease post-mortem brains. The age of disease onset can be predicted partially from the length of the CAG repeat as measured in blood. Onset age is also determ...

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Literature Corpus work: 66a48629-683a-56b4-950e-7c146e469f36
DOI: 10.1101/2023.12.15.571088

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