Article
Mutant huntingtin impairs Ku70-mediated DNA repair.
The Journal of cell biology - 3 May 2010
Enokido Yasushi, Tamura Takuya, Ito Hikaru, Arumughan Anup, Komuro Akihiko, Shiwaku Hiroki, Sone Masaki, Foulle Raphaele, Sawada Hirohide, Ishiguro Hiroshi, Ono Tetsuya, Murata Miho, Kanazawa Ichiro, Tomilin Nikolai, Tagawa Kazuhiko, Wanker Erich E, Okazawa Hitoshi
Abstract excerpt
DNA repair defends against naturally occurring or disease-associated DNA damage during the long lifespan of neurons and is implicated in polyglutamine disease pathology. In this study, we report that mutant huntingtin (Htt) expression in neurons causes double-strand breaks (DSBs) of genomic DNA, and Htt further promotes DSBs by impairing DNA repair. We identify Ku70, a component of the DNA damage repair complex,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.