Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.

Human molecular genetics - 15 Jan 2017

Maiuri Tamara, Mocle Andrew J, Hung Claudia L, Xia Jianrun, van Roon-Mom Willeke M C, Truant Ray

Abstract excerpt

Huntington's disease (HD) is an age-dependent neurodegenerative disease. DNA repair pathways have recently been implicated as the most predominant modifiers of age of onset in HD patients. We report that endogenous huntingtin protein directly participates in oxidative DNA damage repair. Using novel chromobodies to detect endogenous human huntingtin in live cells, we show that localization of huntingtin to DNA...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Ataxia Telangiectasia Mutated Proteins
Share to DNA Damage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Repair

Share to Fibroblasts

Share to Huntingtin Protein

Share to Huntington Disease

Share to Oxidative Stress

Share to Reactive Oxygen Species

Source

Identifiers

PMID: 28017939
DOI: 10.1093/hmg/ddw395

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.PMID 28017939Read ↗

WWOX contributes to DNA damage, but not somatic instability in Huntington’s diseaseSemantic proximity Read ↗

Direct Measure of DNA Damage in Huntington Disease Reveals Elevated Oxidative Genotoxic Stress and Dysfunctional DNA RepairSemantic proximity Read ↗

Characterization of huntingtin interactomes and their dynamic responses in living cells by proximity proteomics.Semantic proximity Read ↗

Targeted quantification assays for DNA repair and handling proteins and interactions in Huntington’s disease modelsSemantic proximity Read ↗

Mutant huntingtin impairs Ku70-mediated DNA repair.Semantic proximity Read ↗

Huntingtin interactome reveals huntingtin role in regulation of double strand break DNA damage response (DSB/DDR), chromatin remodeling and RNA processing pathwaysSemantic proximity Read ↗

Mutations of the Huntington's disease protein impact on the ATM-dependent signaling and repair pathways of the radiation-induced DNA double-strand breaks: corrective effect of statins and bisphosphonates.Semantic proximity Read ↗

Modifications of p53 and the DNA damage response in cells expressing mutant form of the protein huntingtin.Semantic proximity Read ↗

HAP40 is a conserved central regulator of Huntingtin and a specific modulator of mutant Huntingtin toxicitySemantic proximity Read ↗

Poly ADP-Ribose Signaling is Dysregulated in Huntington DiseaseSemantic proximity Read ↗

HYPK, a Huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal Huntingtin with 40 glutamines in Neuro2a cells and exhibits chaperone-like activity.Semantic proximity Read ↗

Cancer: From Wild-Type to Mutant Huntingtin.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.