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Article

SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation.

Cell reports - 25 Jul 2013

O'Rourke Jacqueline Gire, Gareau Jaclyn R, Ochaba Joseph, Song Wan, Raskó Tamás, Reverter David, Lee John, Monteys Alex Mas, Pallos Judit, Mee Lisa, Vashishtha Malini, Apostol Barbara L, Nicholson Thomas Peter, Illes Katalin, Zhu Ya-Zhen, Dasso Mary, Bates Gillian P, Difiglia Marian, Davidson Beverly, Wanker Erich E, Marsh J Lawrence, Lima Christopher D, Steffan Joan S, Thompson Leslie M

Abstract excerpt

A key feature in Huntington disease (HD) is the accumulation of mutant Huntingtin (HTT) protein, which may be regulated by posttranslational modifications. Here, we define the primary sites of SUMO modification in the amino-terminal domain of HTT, show modification downstream of this domain, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23871671
DOI: 10.1016/j.celrep.2013.06.034
PMCID: PMC3931302

Genes

HTT
PIAS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23871671-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation.PMID 23871671Read ↗

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SUMO modification of Huntingtin and Huntington's disease pathology.Semantic proximity Read ↗

How Do Post-Translational Modifications Influence the Pathomechanistic Landscape of Huntington's Disease? A Comprehensive Review.Semantic proximity Read ↗

Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity.Semantic proximity Read ↗

A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington diseaseSemantic proximity Read ↗

SUMO2 Protects Against Tau-induced Synaptic and Cognitive DysfunctionSemantic proximity Read ↗

A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington disease.Semantic proximity Read ↗

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Inhibition of UBE2N promotes the clearance of mutant HTT (huntingtin) in HD knock-in mice.Semantic proximity Read ↗

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