Article

Direct Measure of DNA Damage in Huntington Disease Reveals Elevated Oxidative Genotoxic Stress and Dysfunctional DNA Repair

2025-11-23

Abstract excerpt

DNA damage repair (DDR) pathway proteins are genetic modifiers of Huntington disease (HD) age of onset and severity. Deficient DDR in HD at the first steps of poly ADP-ribosylation makes DNA damage quantification by traditional downstream DNA damage response markers inaccurate. Repair Assisted Damage Detection (RADD) allows for an accurate direct assessment of oxidative DNA damage, a DDR pathway in which huntingti...

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Literature Corpus work: d778e24b-f09a-5ec5-8114-f814378e8d45
DOI: 10.1101/2025.11.21.689804

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