Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase.

Human molecular genetics - 17 May 2021

Suart Celeste E, Perez Alma M, Al-Ramahi Ismael, Maiuri Tamara, Botas Juan, Truant Ray

Abstract excerpt

Spinocerebellar Ataxia Type 1 (SCA1) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the ataxin-1 protein. Recent genetic correlational studies have implicated DNA damage repair pathways in modifying the age at onset of disease symptoms in SCA1 and Huntington's Disease, another polyglutamine expansion disease. We demonstrate that both endogenous and transfected ataxin-1...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Ataxia Telangiectasia Mutated Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ataxin-1

Share to Epithelial Cells

Share to Microscopy, Confocal

Share to Peptides

Share to Spinocerebellar Ataxias

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 33772540
DOI: 10.1093/hmg/ddab074

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase.PMID 33772540Read ↗

Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signalled to DNA damage by Ataxia Telangiectasia Mutated kinaseSemantic proximity Read ↗

Identification of genes that modify ataxin-1-induced neurodegeneration.Semantic proximity Read ↗

Identification of the ataxin-1 interaction network and its impact on spinocerebellar ataxia type 1Semantic proximity Read ↗

Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.Semantic proximity Read ↗

Ataxia-telangiectasia and related diseases.Semantic proximity Read ↗

ATM-Dependent and -Independent Gene Expression Changes in Response to Oxidative Stress, Gamma Irradiation, and UV IrradiationSemantic proximity Read ↗

Amino acids in a region of ataxin-1 outside of the polyglutamine tract influence the course of disease in SCA1 transgenic mice.Semantic proximity Read ↗

Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instabilitySemantic proximity Read ↗

Pathogenic Mechanisms of a Polyglutamine-mediated Neurodegenerative Disease, Spinocerebellar Ataxia Type 1Semantic proximity Read ↗

Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice.Semantic proximity Read ↗

Ataxin 1, a SCA1 neurodegenerative disorder protein, is functionally linked to the silencing mediator of retinoid and thyroid hormone receptors.Semantic proximity Read ↗

Identification of a novel phosphorylation site in ataxin-1.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.