Back to search

Article

Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington’s disease

2017-12-03

Abstract excerpt

<h4>ABSTRACT</h4> Huntington’s Disease (HD) is a dominantly inherited neurodegenerative disease caused by alterations in the huntingtin gene ( htt ). Transcriptional dysregulation is an early event in HD progression. Protein acetylation and methylation particularly on histones regulates chromatin structure thereby preventing or facilitating transcription. Although protein acetylation has been found to affect HD...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4eb11e67-ef48-5425-9695-8ee7979c4265
DOI
10.1101/228486
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Systematic genetic interaction studies identify histone demethylase Utx as potential target for ameliorating Huntington’s diseaseDOI 10.1101/228486
HDAC inhibition imparts beneficial transgenerational effects in Huntington's disease mice via altered DNA and histone methylation.Semantic proximity
A putative role for genome-wide epigenetic regulatory mechanisms in Huntington’s disease: A computational assessmentSemantic proximity
Altered histone monoubiquitylation mediated by mutant huntingtin induces transcriptional dysregulation.Semantic proximity
Transcriptional modulator <i>H2A histone family, member Y</i> ( <i>H2AFY</i> ) marks Huntington disease activity in man and mouseSemantic proximity
ATRX induction by mutant huntingtin via Cdx2 modulates heterochromatin condensation and pathology in Huntington's disease.Semantic proximity
Altered Huntingtin-Chromatin Interactions Predict Transcriptional and Epigenetic Changes in Huntington’s Disease Mouse ModelsSemantic proximity
Histone demethylase KDM5C is a SAHA-sensitive central hub at the crossroads of transcriptional axes involved in multiple neurodevelopmental disorders.Semantic proximity
Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.Semantic proximity
Epigenetic mechanisms governing cell type specific somatic expansion and toxicity in Huntington’s diseaseSemantic proximity
Htt CAG repeat expansion confers pleiotropic gains of mutant huntingtin function in chromatin regulation.Semantic proximity
Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs.Semantic proximity
Targeted quantification assays for DNA repair and handling proteins and interactions in Huntington’s disease modelsSemantic proximity
Select a neighboring publication to make it the new centre.