Article

Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signalled to DNA damage by Ataxia Telangiectasia Mutated kinase

2019-07-13

Abstract excerpt

<h4>ABSTRACT</h4> Spinocerebellar Ataxia Type 1 (SCA1) is an autosomal dominant neurodegenerative disorder caused by a polyglutamine expansion in the ataxin-1 protein. Recent genetic correlational studies have implicated DNA damage repair pathways in modifying the age at onset of disease symptoms in SCA1 and Huntington’s Disease, another polyglutamine expansion disease. We demonstrate that both endogenous and tra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d5f8d413-db67-598d-9843-f2b2a155859e
DOI: 10.1101/701953

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signalled to DNA damage by Ataxia Telangiectasia Mutated kinaseDOI 10.1101/701953Read

Spinocerebellar Ataxia Type 1 protein Ataxin-1 is signaled to DNA damage by ataxia-telangiectasia mutated kinase.Semantic proximity Read

Identification of the ataxin-1 interaction network and its impact on spinocerebellar ataxia type 1Semantic proximity Read

Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNA damage repair in SCA1.Semantic proximity Read

Identification of genes that modify ataxin-1-induced neurodegeneration.Semantic proximity Read

Ataxia-telangiectasia and related diseases.Semantic proximity Read

ATM-Dependent and -Independent Gene Expression Changes in Response to Oxidative Stress, Gamma Irradiation, and UV IrradiationSemantic proximity Read

Preserving protein homeostasis prevents motor impairment in DNA Damage Response-compromised <i>C. elegans</i>Semantic proximity Read

Ataxia telangiectasia derived iPS cells show preserved x-ray sensitivity and decreased chromosomal instabilitySemantic proximity Read

Regulation of transcription patterns, poly-ADP-ribose, and RNA-DNA hybrids by the ATM protein kinaseSemantic proximity Read

Current and potential therapeutic strategies for the treatment of ataxia-telangiectasia.Semantic proximity Read

RpA1 ameliorates symptoms of mutant ataxin-1 knock-in mice and enhances DNA damage repair.Semantic proximity Read

Expansion, mosaicism and interruption: mechanisms of the CAG repeat mutation in spinocerebellar ataxia type 1Semantic proximity Read