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Article

Activation of the DNA damage response in vivo in synucleinopathy models of Parkinson’s disease

26 Jul 2018

Abstract excerpt

The involvement of DNA damage and repair in aging processes is well established. Aging is an unequivocal risk factor for chronic neurodegenerative diseases, underscoring the relevance of investigations into the role that DNA alterations may have in the pathogenesis of these diseases. Consistently, even moderate impairment of DNA repair systems facilitates the onset of pathological features typical of PD that...

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PMID: 30050065
DOI: 10.1038/s41419-018-0848-7

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