Article

Exploring microglial activation and neurodegeneration following traumatic brain injury

2016-01-01

Abstract excerpt

Traumatic brain injury (TBI) patients may deteriorate months and years after injury, developing unforeseen consequences such as dementia. However, the mechanisms relating acute injury to later neurodegeneration are unclear. The positron emission tomography (PET) ligand [11C]-Pittsburgh compound B ([11C]PIB) detects Aβ plaques, a hallmark of Alzheimer’s disease. I found [11C]PIB binding in long-term survivors of mo...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e8b3e83c-ae26-5656-902d-585f667bd081
DOI: 10.25560/55105

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exploring microglial activation and neurodegeneration following traumatic brain injuryDOI 10.25560/55105Read

Traumatic Brain Injury Accelerates the Onset of Cognitive Dysfunction and Aggravates Alzheimer’s-like Pathology in the Hippocampus by Altering the Phenotype of Microglia in APP/PS1 Mouse ModelSemantic proximity Read

From Traumatic Brain Injury to Alzheimer’s Disease: Multilevel Biomechanical, Neurovascular and Molecular Mechanisms with Emerging Therapeutic DirectionsSemantic proximity Read

Long-Term Cognitive Deficits After Traumatic Brain Injury Associated With Microglia ActivationSemantic proximity Read

History of Traumatic Brain Injury with Loss of Consciousness and APOE ε4 Carriers Synergistically Increase Late-Life Amyloid PET BurdenSemantic proximity Read

Thyroid Hormone T4 Mitigates Traumatic Brain Injury by Dynamically Remodeling Cell Type Specific Genes, Pathways, and Networks in Hippocampus and Frontal CortexSemantic proximity Read

Biomarkers of neurodegeneration in post-traumatic stress disorder: an integrative reviewSemantic proximity Read

NLRP3 inhibition maintains microglia architecture and enhances behavioral recovery after traumatic brain injurySemantic proximity Read

Traumatic Brain Injury Induces Tau Aggregation and SpreadingSemantic proximity Read

Accumulation of amyloid in cognitive impairment after mild traumatic brain injury.Semantic proximity Read

Trajectories of blood-based protein biomarkers in chronic traumatic brain injurySemantic proximity Read

Diverse Changes in Microglia Morphology and Axonal Pathology Over One Year after Mild Traumatic Brain Injury in PigsSemantic proximity Read

Positron emission tomography imaging of neuroinflammation in Multiple Sclerosis with a second generation translocator protein PET radioligandSemantic proximity Read