Article

NLRP3 inhibition maintains microglia architecture and enhances behavioral recovery after traumatic brain injury

2025-06-26

Abstract excerpt

<h4>SUMMARY</h4> NLRP3 plays an essential role in secondary neuroinflammatory damage following traumatic brain injury (TBI). However, the specific mechanisms mediating NLRP3’s effects in TBI remain poorly understood, and it is unknown whether its pharmacological inhibition with oral compounds during initial phases confers long-term protection. In this study, we investigated the role of the NLRP3 inflammasome path...

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Literature Corpus work: dfb90f8f-c3e7-572d-a86a-114d9be6cd65
DOI: 10.1101/2025.06.25.660862

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