Article

History of Traumatic Brain Injury with Loss of Consciousness and APOE ε4 Carriers Synergistically Increase Late-Life Amyloid PET Burden

2026-04-20

Abstract excerpt

<h4>Background</h4> Traumatic brain injury with loss of consciousness (TBI-LOC) is an established risk factor for dementia, yet the pathways linking remote TBI to Alzheimer’s disease (AD) biology remain incompletely defined. APOE ε4 is the strongest genetic predictor of amyloid accumulation in late-onset AD, it may moderate the long-term consequences of head injury. This study investigates whether history TBI-LOC...

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Literature Corpus work: 441c5e15-f71b-5ee9-aae5-3d147b401d88
DOI: 10.64898/2026.04.14.717801

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