Article

Diverse Changes in Microglia Morphology and Axonal Pathology Over One Year after Mild Traumatic Brain Injury in Pigs

2020-10-17

Abstract excerpt

Over 2.8 million people experience mild traumatic brain injury (TBI) in the United States each year, which may lead to long-term neurological dysfunction. The mechanical forces that occur due to TBI propagate through the brain to produce diffuse axonal injury (DAI) and trigger secondary neuroinflammatory cascades. The cascades may persist from acute to chronic time points after injury, altering the homeostasis of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9acda0e3-d738-5869-adfe-96063aad8660
DOI: 10.1101/2020.10.16.343103

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Diverse Changes in Microglia Morphology and Axonal Pathology Over One Year after Mild Traumatic Brain Injury in PigsDOI 10.1101/2020.10.16.343103Read

From Traumatic Brain Injury to Alzheimer’s Disease: Multilevel Biomechanical, Neurovascular and Molecular Mechanisms with Emerging Therapeutic DirectionsSemantic proximity Read

Increased CD3 Immunoreactive Cells Persist Chronically in the Brain Parenchyma in Association with Focal Cortical Contusion following Experimental TBISemantic proximity Read

The Central Fluid Percussion Brain Injury in a Gyrencephalic Pig Brain; Scalable Diffuse Injury and Tissue Viability for Glial Cell Immunolabeling Following Long-Term Refrigerated StorageSemantic proximity Read

Functional neurological symptom disorder (conversion disorder): A role for microglial-based plasticity mechanisms?Semantic proximity Read

Traumatic brain injury results in unique microglial and astrocyte transcriptomes enriched for type I interferon responseSemantic proximity Read

Controlled Cortical Impact and Craniotomy Induce Strikingly Similar Profiles of Inflammatory Gene Expression, but with Distinct KineticsSemantic proximity Read

Repetitive mild traumatic brain injury elicits a reactive microglial morphology and elevates serum neurofilament light levels, independent of NLRP3 inflammasome inhibitionSemantic proximity Read

Spatial distribution of neuropathology and neuroinflammation elucidate the biomechanics of fluid percussion injurySemantic proximity Read

Evolution of neurofilament subtype accumulation in axons following diffuse brain injury in the pig.Semantic proximity Read

Time-Dependent Changes in Microglia Transcriptional Networks Following Traumatic Brain InjurySemantic proximity Read

Evidence for the Transient Presence of Atypical Astrocytes in Mice Following a Single, Closed-Head Mild Traumatic Brain InjurySemantic proximity Read

Progression of reactive gliosis and astroglial phenotypic changes following stab wound-induced traumatic brain injury in mice.Semantic proximity Read