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Thyroid Hormone T4 Mitigates Traumatic Brain Injury by Dynamically Remodeling Cell Type Specific Genes, Pathways, and Networks in Hippocampus and Frontal Cortex

2022-11-15

Abstract excerpt

<h4>Background</h4> The complex pathology of mild traumatic brain injury (mTBI) is a main contributor to the difficulties in achieving a successful therapeutic regimen. Thyroxine (T4) administration has been shown to prevent the cognitive impairments induced by mTBI in mice. <h4>Method</h4> To understand the underlying mechanism, we carried out a single cell transcriptomic study to investigate the spatiotemporal...

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Literature Corpus work: 1e001063-3d8f-5574-ac2b-a1ffa0697b15
DOI: 10.1101/2022.11.15.516648

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