Article

Trajectories of blood-based protein biomarkers in chronic traumatic brain injury

2025-02-21

Abstract excerpt

Blood-based protein biomarkers may provide important insights into the long-term neuropathology of traumatic brain injury (TBI). This is urgently required to identify mechanistic processes underlying post-traumatic neurodegeneration (PTND); a progressive post-recovery clinical decline experienced by a portion of TBI survivors. The aim of this study was to examine change over time in protein levels in a chronic TBI...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 5f060d46-bee9-5f17-a660-afba87f8fdc5
DOI: 10.1101/2025.02.16.25322303

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Trajectories of blood-based protein biomarkers in chronic traumatic brain injuryDOI 10.1101/2025.02.16.25322303Read

Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic ActivitySemantic proximity Read

Neuroproteomics and systems biology-based discovery of protein biomarkers for traumatic brain injury and clinical validation.Semantic proximity Read

Elevated plasma MCP-1 concentration following traumatic brain injury as a potential "predisposition" factor associated with an increased risk for subsequent development of Alzheimer's disease.Semantic proximity Read

Blood-Based CNS-Injury and Inflammation Biomarkers Sampled at Acute, Subacute, and Chronic phases After Mild TBI Demonstrate Diagnostic Utility For Patients With and Without Intracranial Injuries on Acute CT and MRISemantic proximity Read

Fluid Proteomics of CSF and Serum Reveal Important Neuroinflammatory Proteins in Blood-Brain Barrier Disruption and Outcome Prediction following Severe Traumatic Brain Injury: a Prospective, Observational StudySemantic proximity Read

Complex Autoantibody Responses Occur Following Moderate to Severe Traumatic Brain InjurySemantic proximity Read

Interrogating the plasma proteome of repetitive head impact exposure and chronic traumatic encephalopathySemantic proximity Read

αII-Spectrin Breakdown Product Cerebrospinal Fluid Exposure Metrics Suggest Differences in Cellular Injury Mechanisms after Severe Traumatic Brain InjurySemantic proximity Read

Protein Predictors of Worsening Cerebral Edema in Traumatic Brain Injury in Critically Ill PatientsSemantic proximity Read

Exploring the role of generalized health biomarkers in Traumatic Brain Injury: A UK Biobank StudySemantic proximity Read

Neurofilament Light Protein: a marker for injury severity, clinical course and outcome following moderate-severe Traumatic Brain InjurySemantic proximity Read

Thyroid Hormone T4 Mitigates Traumatic Brain Injury by Dynamically Remodeling Cell Type Specific Genes, Pathways, and Networks in Hippocampus and Frontal CortexSemantic proximity Read