Article

From Traumatic Brain Injury to Alzheimer’s Disease: Multilevel Biomechanical, Neurovascular and Molecular Mechanisms with Emerging Therapeutic Directions

2026-01-13

Abstract excerpt

Traumatic brain injury (TBI) is increasingly recognized as a major risk factor for chronic neurodegenerative disease, including chronic traumatic encephalopathy (CTE) and Alzheimer’s disease (AD). Biomechanical forces during head trauma, particularly rota-tional acceleration and angular deformation, produce diffuse axonal injury (DAI) and widespread white matter damage that trigger persistent neurobiological casca...

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Literature Corpus work: c0a495c6-d467-5c2e-b8ce-eb12861d1004
DOI: 10.20944/preprints202601.0961.v1

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