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Traumatic Brain Injury Induces Tau Aggregation and Spreading

18 Jul 2019

Abstract excerpt

The misfolding and aggregation of tau protein into neurofibrillary tangles is the main underlying hallmark of tauopathies. Most tauopathies have a sporadic origin and can be associated with multiple risk factors. Traumatic brain injury (TBI) has been suggested as a risk factor for tauopathies by triggering disease onset and facilitating its progression. Several studies indicate that TBI seems to be a risk factor...

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PMID: 31317824
DOI: 10.1089/neu.2018.6348

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