Article

The cilia enriched oxysterol 7β,27-DHC is required for polycystin activation

2022-04-14

Abstract excerpt

PC-1 and PC-2 form a heteromeric ion channel complex (hereafter called the Polycystin complex) that is abundantly expressed on primary cilia of renal epithelial cells. Mutations within the polycystin complex cause Autosomal Dominant Polycystic Kidney Disease (ADPKD). The Polycystin complex forms a non-selective cation channel, yet the spatial and temporal regulation of the polycystin complex within the ciliary mem...

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Literature Corpus work: e8905a1d-3468-5247-ab72-7e2441086f68
DOI: 10.1101/2022.04.13.488122

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