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Ciliary G-Protein Coupled Receptor Signaling in Polycystic Kidney Disease

22 May 2025

Abstract excerpt

genes, disrupts renal structure and function, leading to progressive renal failure. The primary cilium, a sensory organelle essential for cellular signaling, plays a pivotal role in maintaining renal function. Among its signaling components, G-protein-coupled receptors (GPCRs) within the cilium have gained significant attention for their localized functions and their contribution to PKD pathogenesis. Dysfunction...

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PMID: 40507782
DOI: 10.3390/ijms26114971

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