Article

Polycystin-1 acts as an atypical adhesion GPCR that responds to novel Wnt signaling and mechanical stimuli

2025-05-22

Abstract excerpt

Mutations in the genes encoding Polycystin-1 and 2 cause autosomal dominant polycystic kidney disease (ADPKD). These proteins’ cellular functions and the mechanisms through which their absence causes disease are unknown. We find that the behavior of the 11 transmembrane domain polycystin-1 protein resembles that of an adhesion G protein-coupled receptor when activated by Wnt ligands. Exposure to Wnt ligands causes...

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Literature Corpus work: 38fbd589-84e6-5d84-bb0f-e31ec8e84074
DOI: 10.1101/2025.05.21.655326

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