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Article

Polycystin-1: function as a mechanosensor.

The international journal of biochemistry & cell biology - 1 Oct 2010

Dalagiorgou Georgia, Basdra Efthimia K, Papavassiliou Athanasios G

Abstract excerpt

Polycystin-1 (PC1), encoded by the Pkd1 gene, is a large transmembrane protein whose mutation is involved in autosomal dominant polycystic kidney disease. When expressed, PC1 activates a G-protein signaling pathway that subsequently modulates Ca(2+) channels. PC1 is highly expressed in developing tissue and via its C-terminus tail forms a complex with polycystin-2; this complex, found to be located at the primary...

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Source

Identifiers

PMID: 20601082
DOI: 10.1016/j.biocel.2010.06.017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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