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Cholesterol ensures ciliary polycystin-2 localization to prevent polycystic kidney disease

3 Feb 2025

Abstract excerpt

The plasma membrane covering the primary cilium has a diverse accumulation of receptors and channels. To ensure the sensor function of the cilia, the ciliary membrane has higher cholesterol content than other cell membrane regions. A peroxisomal biogenesis disorder, Zellweger syndrome, characterized by polycystic kidney, is associated with a reduced level of ciliary cholesterol in cells. However, the etiological...

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PMID: 39900437
DOI: 10.26508/lsa.202403063

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