Defining the Polycystin Pharmacophore Through HTS & Computational Biophysics

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background and Purpose</h4> Polycystins (PKD2, PKD2L1) are voltage-gated and Ca 2+ -modulated members of the transient receptor potential (TRP) family of ion channels. Loss of PKD2L1 expression results in seizure-susceptibility and autism-like features in mice, whereas variants in PKD2 cause autosomal dominant polycystic kidney disease. Despite decades of evidence clearly linking their dys...

Topics

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• Calcium Channels
• Ion Transport
• Mice
• Mutation
• Receptors, Cell Surface
• Signal Transduction
• Transient Receptor Potential Channels
• TRPP Cation Channels

Identifiers and source

Literature Corpus work

2bdfaecf-c6a7-5d43-a17e-453c199c1e40

DOI

10.1101/2025.01.13.632808