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Article

The Polycystin-1, Lipoxygenase, and α-Toxin Domain Regulates Polycystin-1 Trafficking.

Journal of the American Society of Nephrology : JASN - 1 Apr 2016

Xu Yaoxian, Streets Andrew J, Hounslow Andrea M, Tran Uyen, Jean-Alphonse Frederic, Needham Andrew J, Vilardaga Jean-Pierre, Wessely Oliver, Williamson Michael P, Ong Albert C M

Abstract excerpt

Mutations in polycystin-1 (PC1) give rise to autosomal dominant polycystic kidney disease, an important and common cause of kidney failure. Despite its medical importance, the function of PC1 remains poorly understood. Here, we investigated the role of the intracellular polycystin-1, lipoxygenase, and α-toxin (PLAT) signature domain of PC1 using nuclear magnetic resonance, biochemical, cellular, and in vivo...

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Identifiers

PMID: 26311459
DOI: 10.1681/ASN.2014111074
PMCID: PMC4814171

Genes

PLAT

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