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Article

Cilia-enriched oxysterol 7β,27-DHC is required for polycystin ion channel activation.

Nature communications - 31 Jul 2024

Ha Kodaji, Mundt-Machado Nadine, Bisignano Paola, Pinedo Aide, Raleigh David R, Loeb Gabriel, Reiter Jeremy F, Cao Erhu, Delling Markus

Abstract excerpt

Polycystin-1 (PC-1) and PC-2 form a heteromeric ion channel complex that is abundantly expressed in primary cilia of renal epithelial cells. This complex functions as a non-selective cation channel, and mutations within the polycystin complex cause autosomal dominant polycystic kidney disease (ADPKD). The spatial and temporal regulation of the polycystin complex within the ciliary membrane remains poorly...

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PMID: 39085216
DOI: 10.1038/s41467-024-50318-9
PMCID: PMC11291729

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PC

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Cilia-enriched oxysterol 7β,27-DHC is required for polycystin ion channel activation.PMID 39085216Read ↗

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