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Article

Polycystin-2 (PC2): structural insights and its role in disease pathogenesis.

Archives of physiology and biochemistry - 1 Aug 2026

Luo Jingwei, Peng Keshan, Huang Xuehong, Chen Yueting, Liu Xiangting, Li Wan, Jian Jie, Lu Jun

Abstract excerpt

CONTEXT: Polycystin-2 (PC2), a calcium-permeable ion channel, is localised to the endoplasmic reticulum, plasma membrane, and primary cilium. Mutations in PC2 are linked diseases, such as autosomal dominant polycystic kidney disease (ADPKD), cardiovascular disorders, and cancer. OBJECTIVE: This review highlights the structural features, distribution, and regulatory mechanisms of PC2, emphasising its involvement...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41660870
DOI: 10.1080/13813455.2026.2628182

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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