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Article

The heteromeric PC-1/PC-2 polycystin complex is activated by the PC-1 N-terminus.

eLife - 9 Nov 2020

Ha Kotdaji, Nobuhara Mai, Wang Qinzhe, Walker Rebecca V, Qian Feng, Schartner Christoph, Cao Erhu, Delling Markus

Abstract excerpt

Mutations in the polycystin proteins, PC-1 and PC-2, result in autosomal dominant polycystic kidney disease (ADPKD) and ultimately renal failure. PC-1 and PC-2 enrich on primary cilia, where they are thought to form a heteromeric ion channel complex. However, a functional understanding of the putative PC-1/PC-2 polycystin complex is lacking due to technical hurdles in reliably measuring its activity. Here we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33164752
DOI: 10.7554/eLife.60684
PMCID: PMC7728438

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