Article

An Optimally Weighted Combination Method to Detect Novel Disease Associated Genes Using Publicly Available GWAS Summary Data

2019-07-20

Abstract excerpt

Gene-based analyses offer a useful alternative and complement to the usual single nucleotide polymorphism (SNP) based analysis for genome-wide association studies (GWASs). Using appropriate weights (pre-specified or eQTL-derived) can boost statistical power, especially for detecting weak associations between a gene and a trait. Because the sparsity level or association directions of the underlying association patt...

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Literature Corpus work: e866d052-2ac0-5345-83a7-7b5a0eb12c7f
DOI: 10.1101/709808

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