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Article

A comprehensive comparison of multilocus association methods with summary statistics in genome-wide association studies.

BMC bioinformatics - 30 Aug 2022

Shao Zhonghe, Wang Ting, Qiao Jiahao, Zhang Yuchen, Huang Shuiping, Zeng Ping

Abstract excerpt

BACKGROUND: Multilocus analysis on a set of single nucleotide polymorphisms (SNPs) pre-assigned within a gene constitutes a valuable complement to single-marker analysis by aggregating data on complex traits in a biologically meaningful way. However, despite the existence of a wide variety of SNP-set methods, few comprehensive comparison studies have been previously performed to evaluate the effectiveness of...

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PMID: 36042399
DOI: 10.1186/s12859-022-04897-3
PMCID: PMC9429742

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