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Article

Detecting association of rare and common variants by testing an optimally weighted combination of variants.

Genetic epidemiology - 1 Sept 2012

Sha Qiuying, Wang Xuexia, Wang Xinli, Zhang Shuanglin

Abstract excerpt

Next-generation sequencing technology will soon allow sequencing the whole genome of large groups of individuals, and thus will make directly testing rare variants possible. Currently, most of existing methods for rare variant association studies are essentially testing the effect of a weighted combination of variants with different weighting schemes. Performance of these methods depends on the weights being used...

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PMID: 22714994
DOI: 10.1002/gepi.21649

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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