Article
A fast and powerful eQTL weighted method to detect genes associated with complex trait using GWAS summary data.
Genetic epidemiology - 1 Sept 2020
Zhang Jianjun, Xie Sicong, Gonzales Samantha, Liu Jianguo, Wang Xuexia
Abstract excerpt
Although genomewide association studies (GWASs) have identified many genetic variants underlying complex traits, a large fraction of heritability still remains unexplained. Integrative analysis that incorporates additional information, such as expression quantitativetrait locus (eQTL) data into sequencing studies (denoted as transcriptomewide association study [TWAS]), can aid the discovery of trait-associated...
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