Article

System-wide extraction of cis-regulatory rules from sequence-to-function models in human neural development

2026-01-14

Abstract excerpt

The genomic cis -regulatory code (CRC) underlies spatiotemporal specificity of gene expression. While sequence-to-function (S2F) models can accurately encode the CRC of transcriptional enhancers, decoding these models into human-interpretable rules remains a major challenge. Here we tackle this challenge in human neural development, for which we generate two new single-cell multiome atlases, one from a human embr...

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Literature Corpus work: e85daf55-6d9d-503b-a060-04bfaac48991
DOI: 10.64898/2026.01.14.699402

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