Article

Billion-Scale Deciphering of Human Gene Regulatory Grammar

2025-11-10

Abstract excerpt

Predicting how DNA sequence specifies gene expression remains a core challenge across regulatory genomics. Most predictive assays and models depend on native genomic DNA, constraining the full biochemical engineering space for assessing and designing new sequences. Here, we address this gap with a scalable experimental–computational platform that rapidly generates million-scale sequence-to-expression datasets that...

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Literature Corpus work: d9d57254-ce8c-5b4f-8c6a-20187f476757
DOI: 10.1101/2025.11.10.687627

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