Article

Massively parallel characterization of psychiatric disorder-associated and cell-type-specific regulatory elements in the developing human cortex

2023-02-15

Abstract excerpt

Nucleotide changes in gene regulatory elements are important determinants of neuronal development and disease. Using massively parallel reporter assays in primary human cells from mid-gestation cortex and cerebral organoids, we interrogated the cis -regulatory activity of 102,767 sequences, including differentially accessible cell-type specific regions in the developing cortex and single-nucleotide variants assoc...

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Literature Corpus work: 32680159-7495-5919-89b2-24f0c0474ce4
DOI: 10.1101/2023.02.15.528663

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