Article

CREaTor: Zero-shot <i>cis</i> -regulatory pattern modeling with attention mechanisms

2023-03-29

Abstract excerpt

Linking cis -regulatory sequences to target genes has been a long-standing challenge. In this study, we introduce CREaTor, an attention-based deep neural network designed to model cis -regulatory patterns for genomic elements up to 2Mb from target genes. Coupled with a training strategy that predicts gene expression from flanking candidate cis -regulatory elements (cCREs), CREaTor can model cell type-specific...

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Literature Corpus work: cd08d9ca-dc49-5646-b917-9950b90b97e0
DOI: 10.1101/2023.03.28.534267

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